Optimized oxidoreductases for medium and large scale industrial biotransformations
Project Secretariat
Dr Marta Pérez-Boada
E-mail: MPBoada@cib.csic.es
Consejo Superior de Investigaciones Científicas (CSIC)
Biological Research Centre (CIB)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain
Phone: 34 918373112
Fax: 34 915360432
Mobile: 34 650080476
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about us
AnaxomicsAnaxomics, Barcelona, Spain (AX)

V. Guallar

J. Farres
Contact information
V. Guallar, ICREA Professor, and
J. Farres, PhD, Head of Collaborative Research, Balmes 29, 08008 Barcelona, Spain.

Phone: +34 934516717 (Judith)
+34 934137727 (Victor);
E-mail: judith@anaxomics.com and guallarv@gmail.com

Description of the group
AX is an SME offering integrative solutions based on systems biology and molecular simulations approaches. The companyhas developed Therapeutic Performance Mapping System, a proprietary technology (61/255,299 (US)), which allows the integration of all biochemical information and molecular relationships in a complex molecular network. AX has recently been listed in the top 100 most innovative European companies by Red Herring 2011.

Ligand (veratryl-VA) migration in lignin peroxidase modeled by PELE is shown in shade-brown tubes representation (a total of 6 different snapshots along the migration). In RED/BLUE we show the total spin density for the three unpaired electrons in compound I showing the oxidation of the substrate by the HEME group
For the INDOX project AX will count on the expertise of Prof. Victor Guallar, recipient of an Advanced IDEAS ERC grant with more than 80 publications, who has developed state-of-the-art technologies in molecular modeling including ligand migration (PELE software) and QM/MM techniques.

Main role in INDOX
The main role will be the aiding in the structural-functional studies and in the rational design of the biocatalysts. Simulations mapping substrate migration/binding and its oxidation will be conducted for the wild type and for several mutants. These simulations will complement the enzymatic structural-functional studies by correlating the experimental work with the theoretical atomic detailed mechanism. For this purpose, a diverse set of state of the art software together with massive parallel computing will be used.
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Project Coordinator
Prof. Angel T. Martínez
Biological Research Centre (CIB, CSIC)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain.
E-mail: ATMartinez@cib.csic.es
Phone: 34 918373112
Fax: 34 915360432

Angel T. Martínez is Research Professor of CSIC at the group of Biotechnology for Lignocellulosic Biomass of CIB. He is member of ACS, ASM and TAPPI, with around 250 publications mainly related to oxidoreductases and microbial biotechnology.

His experience is supported by participation in more than 55 national and international research projects, in most of them as head researcher. Regarding EC Framework Programmes, he has coordinated projects of Industrial Biotechnology from FP3 to FP7, such as PEROXICATS (KBBE-2010-4-265397), BIORENEW (NMP2-CT-2006-026456), PELAS (QLK3-1999-00590), PITCH (QLK5-1999-01357) and AIR2 (CT93-1219).
Official webpage of indox [ industrialoxidoreductases ]. Optimized oxidoreductases for medium and large scale industrial biotransformations. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: FP7-KBBE-2013-7-613549. © indox 2013. Developed by garcíarincón