Optimized oxidoreductases for medium and large scale industrial biotransformations
Project Secretariat
Dr Marta Pérez-Boada
E-mail: MPBoada@cib.csic.es
Consejo Superior de Investigaciones Científicas (CSIC)
Biological Research Centre (CIB)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain
Phone: 34 918373112
Fax: 34 915360432
Mobile: 34 650080476
Private area


about us
NovozymesNovozymes A/S, Bagsvaerd, Denmark (NZ)

Henrik Lund
Contact information
H. Lund, Director, Technical Applications, Novozymes A/S, Krogshoejvej 36, 2880-Bagsvaerd, Denmark

Phone: 45 44468502/Mobile 45 30778502
Fax: 45 4446 9999
E-mail: Hlu@novozymes.com

Description of the group
NZ is world leader in bio-innovation and the world largest producer of industrial enzymes, with a 45% market share. Its over 700 products are used in more than 40 industries to improve processes and quality, and save water, energy, raw materials and waste. In 2011 NZ reported sales of 1400 million € and spend around 13-14% of its turnover on R&D. It is headquartered in Denmark and employs ~6000 people in 30 countries, with production plants in Denmark, US, China, Brazil and India.

Several groups within NZ R&D organization will be involved in INDOX. The Technical Applications group is responsible for enzyme product and process development within a range of process industries, including enzymes for use in chemical processing. The group (headed by Henrik Lund) has around 25 people dedicated to the above areas. The following scientists are expected to significantly contribute to the project: Lisbeth Kalum, Sr. science manager specialized in oxidoreductase for advanced oxidation reactions; Ingrida Lapenaite, Research scientist specialized in GC-MS and LC-MS analysis of industrial chemicals and their manufacture via enzymatic catalysis; and Jacob Skibsted Jensen, Research Scientist specialized in up-scaling of chemical reactions; process modeling and technical thermodynamics.

Jesper Vind
The Protein Diversity department (headed by Lars Beier) is specialized in protein engineering to adapt enzyme specificity and stability for industrial application. Jesper Vind, Sr.Sc. manager specialized in optimizing enzymes including peroxygenases (with contributions in basidiomycete CIP cloning, expression, crystal structure, substrate binding, site-directed mutagenesis, and directed evolution) will be in charge of this part of the project.

Main role in INDOX
The main contributions of NZ will be:
i) to adapt enzymes to the industrial process conditions taking advantage from its large facilities for protein engineering (robotized systems, etc);
ii) expression of enzymes and providing them to partners;
iii) development of multi-enzymatic systems;
iv) design of oxyfunctionalization and oxidation processes for new green applications, and
v) leading WP10 (Demonstration activities) to collaborate with the chemical companies in the implementation of bioprocesses.
H. Lund will also take part of the Coordination Team as the project Industrial Manager, promoting dissemination and the use and exploitation of results.
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Project Coordinator
Prof. Angel T. Martínez
Biological Research Centre (CIB, CSIC)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain.
E-mail: ATMartinez@cib.csic.es
Phone: 34 918373112
Fax: 34 915360432

Angel T. Martínez is Research Professor of CSIC at the group of Biotechnology for Lignocellulosic Biomass of CIB. He is member of ACS, ASM and TAPPI, with around 250 publications mainly related to oxidoreductases and microbial biotechnology.

His experience is supported by participation in more than 55 national and international research projects, in most of them as head researcher. Regarding EC Framework Programmes, he has coordinated projects of Industrial Biotechnology from FP3 to FP7, such as PEROXICATS (KBBE-2010-4-265397), BIORENEW (NMP2-CT-2006-026456), PELAS (QLK3-1999-00590), PITCH (QLK5-1999-01357) and AIR2 (CT93-1219).
Official webpage of indox [ industrialoxidoreductases ]. Optimized oxidoreductases for medium and large scale industrial biotransformations. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: FP7-KBBE-2013-7-613549. © indox 2013. Developed by garcíarincón