Optimized oxidoreductases for medium and large scale industrial biotransformations
Project Secretariat
Dr Marta Pérez-Boada
E-mail: MPBoada@cib.csic.es
Consejo Superior de Investigaciones Científicas (CSIC)
Biological Research Centre (CIB)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain
Phone: 34 918373112
Fax: 34 915360432
Mobile: 34 650080476
Private area


Providing industrial case stories to demonstrate the efficacy of oxidative biocatalysts.
Optimizing target enzymatic reactions to obtain products and precursors for the chemical industry and other sectors.
Establishing the processes scalability, sustainability and cost-efficiency versus chemical conversion methods.
Searching for selected groups of oxidoreductases in fungal genomes and other sources.
Engineering improved activity and stability of oxidative enzymes to meet industrial application requirements.
The indox Project is a collaborative research initiative funded by
the European Commission 7th Framework Programme (FP7) that gathers together the expertise of sixteen participants from seven EU countries plus one partner from an EU candidate country.morebrochureDownload our brochure about the project in pdf [1,3Mb]
advances 2017 Biotechnology Advances (2017) Review including INDOX main results
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Related info view all->

Nature to improve the chemical industry - The INDOX EU ProjectAn article highlighting the INDOX project objectives and main outcomes has been included in the “BIOECONOMY INNOVATION –CommBeBiz magazine 2016-2017”, (…) more

5th International Conference on Novel EnzymesOCTOBER 11-14, 2016 / GRONINGEN / THE NETHERLANDS
The 5th international conference on Novel Enzymes (INEC16) aims to provide a forum for the presentation of the most exciting advances and new (…) more

Biochemical engineer Frances Arnold wins 2016 Millennium Technology Prize for "directed evolution" revolutionBiochemical engineer  (…) more

Last publications view all->

The mechanism of dioxygen reduction by the flavoenzyme aryl-alcohol oxidase was investigated with kinetic isotope, viscosity, and pL (pH/pD) effects in rapid kinetics experiments by stopped-flow spectrophotometry of the oxidative (…) more

Sugarcane bagasse and straw, two major agro-industrial byproducts generated by the sugarcane industry, contain significant amounts of carbohydrates that can be hydrolyzed and then converted into ethanol or other valuable compounds. However, access to them (…) more

Vanillyl alcohol oxidase (VAO) is a homo-octameric flavoenzyme belonging to the VAO/PCMH family. Each VAO subunit consists of two domains, the FAD-binding and the cap domain. VAO catalyses, among other reactions, the two-step conversion of p-creosol (…) more

The temperature dependence of hydride transfer from the substrate to the N5 of the FAD cofactor during the reductive half-reaction of Pleurotus eryngii aryl-alcohol oxidase (AAO) is assessed here. Kinetic isotope effects on both the pre-steady state reduction (…) more

External news
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Official webpage of indox [ industrialoxidoreductases ]. Optimized oxidoreductases for medium and large scale industrial biotransformations. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: FP7-KBBE-2013-7-613549. © indox 2013. Developed by garcíarincón